Insulin-like growth factor I (IGF-I) affects plasma lipid profile and inhibits the lipolytic action of growth hormone (GH) in isolated adipocytes

Life Sci. 1995;57(12):1213-8. doi: 10.1016/0024-3205(95)02067-s.

Abstract

The actions of insulin-like growth factor I (IGF-I) and growth hormone (GH) on lipid metabolism have been investigated in hormonally intact rats. The subcutaneous injection of IGF-I (100 micrograms) and GH (100 micrograms) lowered total cholesterol plasma levels. The in vitro assays on isolated rat adipocytes showed an antilipolytic effect of IGF-I on GH induced lipolysis. All these data support an important role for IGF-I and GH on the regulation of lipid metabolism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes / drug effects*
  • Adipocytes / metabolism
  • Animals
  • Cholesterol / blood
  • Fatty Acids, Nonesterified / blood
  • Growth Hormone / antagonists & inhibitors*
  • Growth Hormone / pharmacology
  • Insulin / blood
  • Insulin-Like Growth Factor I / pharmacology*
  • Lipids / blood*
  • Rats
  • Rats, Wistar
  • Time Factors
  • Triglycerides / blood

Substances

  • Fatty Acids, Nonesterified
  • Insulin
  • Lipids
  • Triglycerides
  • Insulin-Like Growth Factor I
  • Growth Hormone
  • Cholesterol