Abstract
The actions of insulin-like growth factor I (IGF-I) and growth hormone (GH) on lipid metabolism have been investigated in hormonally intact rats. The subcutaneous injection of IGF-I (100 micrograms) and GH (100 micrograms) lowered total cholesterol plasma levels. The in vitro assays on isolated rat adipocytes showed an antilipolytic effect of IGF-I on GH induced lipolysis. All these data support an important role for IGF-I and GH on the regulation of lipid metabolism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipocytes / drug effects*
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Adipocytes / metabolism
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Animals
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Cholesterol / blood
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Fatty Acids, Nonesterified / blood
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Growth Hormone / antagonists & inhibitors*
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Growth Hormone / pharmacology
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Insulin / blood
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Insulin-Like Growth Factor I / pharmacology*
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Lipids / blood*
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Rats
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Rats, Wistar
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Time Factors
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Triglycerides / blood
Substances
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Fatty Acids, Nonesterified
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Insulin
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Lipids
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Triglycerides
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Insulin-Like Growth Factor I
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Growth Hormone
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Cholesterol