Abstract
2-Geranylgeranyl-1,4-dihydroxybenzene [1] and a mixture of fatty acid esters of this phenol were isolated from the fruiting bodies of Lactarius lignyotus. Compound 1 was highly active in the brine shrimp test and showed significant inhibitory activity on DNA, RNA, and protein synthesis in HeLa and HL-60 cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Basidiomycota / chemistry*
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DNA, Neoplasm / biosynthesis
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Diterpenes*
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Leucine / metabolism
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Neoplasm Proteins / biosynthesis
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RNA, Neoplasm / biosynthesis
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
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Thymidine / metabolism
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Tumor Cells, Cultured
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Uridine / metabolism
Substances
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DNA, Neoplasm
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Diterpenes
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Neoplasm Proteins
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RNA, Neoplasm
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Terpenes
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geranylgeranylhydroquinone
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Leucine
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Thymidine
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Uridine