A bioactive tetraprenylphenol from Lactarius lignyotus

J Nat Prod. 1995 Jun;58(6):893-6. doi: 10.1021/np50120a011.

Abstract

2-Geranylgeranyl-1,4-dihydroxybenzene [1] and a mixture of fatty acid esters of this phenol were isolated from the fruiting bodies of Lactarius lignyotus. Compound 1 was highly active in the brine shrimp test and showed significant inhibitory activity on DNA, RNA, and protein synthesis in HeLa and HL-60 cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Basidiomycota / chemistry*
  • DNA, Neoplasm / biosynthesis
  • Diterpenes*
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Humans
  • Leucine / metabolism
  • Neoplasm Proteins / biosynthesis
  • RNA, Neoplasm / biosynthesis
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology
  • Thymidine / metabolism
  • Tumor Cells, Cultured
  • Uridine / metabolism

Substances

  • DNA, Neoplasm
  • Diterpenes
  • Neoplasm Proteins
  • RNA, Neoplasm
  • Terpenes
  • geranylgeranylhydroquinone
  • Leucine
  • Thymidine
  • Uridine