Abstract
Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Viral / blood
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B-Lymphocytes / immunology
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Base Sequence
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Chemokine CCL4
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Coxsackievirus Infections / immunology*
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Coxsackievirus Infections / virology
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Cytokines / genetics
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Cytokines / physiology*
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Enterovirus B, Human* / growth & development
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Enterovirus B, Human* / immunology
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Gene Targeting
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Hematopoiesis
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Influenza A virus* / growth & development
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Influenza A virus* / immunology
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Lymphocyte Activation
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Macrophage Inflammatory Proteins
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Mice
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Mice, Inbred C57BL
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Molecular Sequence Data
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Monokines / genetics
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Monokines / physiology*
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Myocarditis / immunology*
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Myocarditis / virology
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Neutralization Tests
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Orthomyxoviridae Infections / immunology*
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Orthomyxoviridae Infections / virology
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Stem Cells
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T-Lymphocytes / immunology
Substances
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Antibodies, Viral
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Chemokine CCL4
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Cytokines
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Macrophage Inflammatory Proteins
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Monokines