Therapy-related acute myeloid leukemia with t(8;16)(p11;p13) following anthracycline-based therapy for nonmetastatic osteosarcoma

H Demuynck; G E Verhoef; P Zachée; P Vandenberghe; A Van Orshoven; R Paridaens; I Samson; M A Boogaerts

doi:10.1016/0165-4608(95)00045-q

Therapy-related acute myeloid leukemia with t(8;16)(p11;p13) following anthracycline-based therapy for nonmetastatic osteosarcoma

Cancer Genet Cytogenet. 1995 Jul 15;82(2):103-5. doi: 10.1016/0165-4608(95)00045-q.

Authors

H Demuynck¹, G E Verhoef, P Zachée, P Vandenberghe, A Van Orshoven, R Paridaens, I Samson, M A Boogaerts

Affiliation

¹ Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium.

PMID: 7664238
DOI: 10.1016/0165-4608(95)00045-q

Abstract

A case of therapy-related AML with t(8;16)(p11;p13) 14 months following the end of anthracycline-containing chemotherapy for a nonmetastatic osteosarcoma of the left tibia is presented. The patient was successfully treated with intensive remission-induction chemotherapy. Subsequently, he underwent an uncomplicated allogeneic bone marrow transplantation from his HLA-identical brother and is at present alive and disease-free 10 months after diagnosis of the secondary AML.

Publication types

Case Reports

MeSH terms

Acute Disease
Adult
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Bone Neoplasms / drug therapy*
Cisplatin / administration & dosage
Doxorubicin / administration & dosage
Humans
Karyotyping
Leukemia, Myeloid / chemically induced
Leukemia, Myeloid / genetics*
Male
Osteosarcoma / drug therapy*
Tibia*
Translocation, Genetic*

Substances

Doxorubicin
Cisplatin