1H and 13C NMR study of the molecular interaction mechanism between chloramphenicol and human serum albumin

Biochem Mol Biol Int. 1995 Feb;35(2):457-60.

Abstract

Molecular mechanism of the interaction between human serum albumin and cloramphenicol was studied by 1H and 13C NMR-spectroscopy. It was found that the main role belongs to [formula: see text] groups of chloramphenicol. A schematic model of the complex-formation between serum albumin and chloramphenicol was proposed.

MeSH terms

  • Binding Sites
  • Carbon Isotopes
  • Chloramphenicol / metabolism*
  • Humans
  • Hydrogen
  • Magnetic Resonance Spectroscopy / methods
  • Models, Structural
  • Protein Binding
  • Protein Conformation
  • Serum Albumin / chemistry*
  • Serum Albumin / metabolism*

Substances

  • Carbon Isotopes
  • Serum Albumin
  • Chloramphenicol
  • Hydrogen