[The effect of hydrodynamic conditions on the interferon-synthesizing activity of swine splenocytes in the production of alpha-interferon]

Mikrobiol Z. 1995 May-Jun;57(3):71-7.
[Article in Russian]

Abstract

Parameters of physical constituents of the agitation process and mass-exchange characteristics of the suggested bioreactor for suspension cultivation of pig splenocytes are determined. The effect of hydrodynamic conditions on viability and interferon-synthesizing activity of cells in production of alpha-interferon of pigs has been studied. The relation existing between interferonogenesis processes proceeding under suspension and under stationary biosynthesis has been analyzed by the pair correlation method.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Cells, Cultured
  • Chemical Phenomena
  • Chemistry
  • Interferon-alpha / biosynthesis*
  • Mathematics
  • Spleen / cytology
  • Spleen / metabolism*
  • Swine

Substances

  • Interferon-alpha