Central hemodynamics, phase structure of left-ventricular systole, and paO2 were studied in 104 patients with organophosphorus poisoning complicated by exotoxic shock during forced ventilation of the lungs (FVL) with positive zero expiration pressure, positive end expiration pressure +5, +7, +10 cm H2O, and high-frequency FVL. FVL with positive end expiration pressure +5 or +10 cm H2O was found to be the optimal for patients with compensated shock. In patients with decompensated phase of exotoxic shock FVL with positive zero expiration pressure and FVL with positive end expiration pressure +5 cm H2O, although having no negative impact on the hemo- and cardiodynamics, did not provide sufficient oxygenation of the blood. Higher values of positive end expiration pressure (+7, +10 cm H2O) brought about disorders of heart work. High-frequency FVL appears to be the most rational in patients with decompensated phase of shock.