Abstract
Transforming growth factor alpha (TGF alpha) is a close relative of epidermal growth factor (EGF), the first polypeptide mitogen discovered in 1962 (Cohen, 1962). TGF alpha, like EGF, exerts its effect on cells through binding to the EGF-Receptor (EGF-R). Here we review the molecular and cell biology of TGF alpha before proceeding to describe our own work on signaling molecules induced in response to activation of the EGF-R.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Transformation, Neoplastic
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Epidermal Growth Factor / chemistry
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ErbB Receptors / physiology*
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Humans
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Models, Biological
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Molecular Sequence Data
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Protein Structure, Secondary
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Psoriasis / pathology
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Psoriasis / physiopathology
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Signal Transduction
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Transforming Growth Factor alpha / chemistry
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Transforming Growth Factor alpha / genetics
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Transforming Growth Factor alpha / physiology*
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ras Proteins / physiology
Substances
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Transforming Growth Factor alpha
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Epidermal Growth Factor
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ErbB Receptors
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ras Proteins