Transforming growth factor alpha

Cell Biol Int. 1995 May;19(5):373-88. doi: 10.1006/cbir.1995.1083.

Abstract

Transforming growth factor alpha (TGF alpha) is a close relative of epidermal growth factor (EGF), the first polypeptide mitogen discovered in 1962 (Cohen, 1962). TGF alpha, like EGF, exerts its effect on cells through binding to the EGF-Receptor (EGF-R). Here we review the molecular and cell biology of TGF alpha before proceeding to describe our own work on signaling molecules induced in response to activation of the EGF-R.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Transformation, Neoplastic
  • Epidermal Growth Factor / chemistry
  • ErbB Receptors / physiology*
  • Humans
  • Models, Biological
  • Molecular Sequence Data
  • Protein Structure, Secondary
  • Psoriasis / pathology
  • Psoriasis / physiopathology
  • Signal Transduction
  • Transforming Growth Factor alpha / chemistry
  • Transforming Growth Factor alpha / genetics
  • Transforming Growth Factor alpha / physiology*
  • ras Proteins / physiology

Substances

  • Transforming Growth Factor alpha
  • Epidermal Growth Factor
  • ErbB Receptors
  • ras Proteins