Abstract
Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for Gag, Pol, and Env, compared with levels present in intermediate and advanced progressors. CD8+ memory cytotoxic T lymphocytes may have an important role in controlling HIV-1 replication and preventing disease in long-term nonprogressors.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / drug therapy
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Acquired Immunodeficiency Syndrome / immunology
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Acquired Immunodeficiency Syndrome / physiopathology*
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Adult
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Aged
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CD4-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / immunology
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DNA, Viral / blood
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HIV Infections / drug therapy
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HIV Infections / immunology
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HIV Infections / physiopathology*
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HIV Seropositivity / drug therapy
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HIV Seropositivity / immunology
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HIV Seropositivity / physiopathology*
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HIV-1 / isolation & purification*
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HIV-1 / physiology
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Humans
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Immunologic Memory*
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Middle Aged
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RNA, Viral / blood
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T-Lymphocytes, Cytotoxic / immunology*