International Commission for Protection Against Environmental Mutagens and Carcinogens. Genetic risk extrapolation from animal data to human disease. A Taskgroup Report. No. 00105

J Favor; D Layton; G Sega; J Wassom; J Burkhart; G Douglas; K Dearfield; D Brusick

doi:10.1016/0027-5107(93)e0261-n

International Commission for Protection Against Environmental Mutagens and Carcinogens. Genetic risk extrapolation from animal data to human disease. A Taskgroup Report. No. 00105

Mutat Res. 1995 Aug;330(1-2):23-34. doi: 10.1016/0027-5107(93)e0261-n.

Authors

J Favor¹, D Layton, G Sega, J Wassom, J Burkhart, G Douglas, K Dearfield, D Brusick

Affiliation

¹ Hazleton Washington Inc., Vienna, VA 22182-1699, USA.

PMID: 7623868
DOI: 10.1016/0027-5107(93)e0261-n

Abstract

This report describes a model for producing quantitative genetic risk assessments for human populations. The model is patterned after current methods used in cancer risk analysis. The risk to humans is expressed as the number of additional dominant genetic diseases added to the existing genetic burden, in the offspring of the exposed individuals.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Carcinogens, Environmental / toxicity*
Dose-Response Relationship, Drug
Environmental Exposure / adverse effects
Genes, Dominant
Germ-Line Mutation*
Humans
Mice
Models, Genetic*
Models, Statistical
Mutagenicity Tests* / methods
Mutagenicity Tests* / standards
Mutagens / toxicity*
Reproducibility of Results
Risk Assessment
Species Specificity
Translocation, Genetic

Substances

Carcinogens, Environmental
Mutagens