The authors discuss the indications for fibrin glue utilization in the sclerosing treatment of angiomas, with particular reference to cavernous and venous angiomas. The sclerosing agent may be employed in connection with embolization and subsequent surgery. The authors have successfully used the interstitial sclerosing technique to obtain the sclerosis of the thin threads of fibrous tissue stroma between blood vessels. The sclerosing therapy may cause the complete regression of "low flow" angiomas or, at least, a partial reduction that simplifies the ensuing surgical excision. In the case of partial regression of the angiomas obtained with the sclerosing therapy, the surgery of the remaining angioma causes a lower degree of bleeding; an increased reliability in the radicality of the intervention (due also to the reduced size of the lesion); and better results from an aesthetic-functional point of view.