In cats raised with surgically induced esotropia and early section of the optic chiasm visually responsive neurons were recorded from areas 17-18 ipsilaterally and contralaterally to the deviated eye. In these animals both cortices were monocularly activated only through the ipsilateral eye. In addition, unlike to that occurring in otherwise intact strabismic animals, the esotropic eye drove a number of neurons equivalent to that driven by the non-deviated eye. We suggest that an inhibitory influence exterted over the ipsilateral afferents of the deviated eye is removed by the early section of the crossed retinal projections.