Abstract
Two tris-indole alkaloids, (+/-) gelliusines A and B [1], have been isolated for the first time from a marine source, the New Caledonian sponge, Orina sp. (or Gellius sp.), along with five further indole constituents [2-6]. Compound 6 has been identified as 2,2-bis-(6'-bromo-3'-indolyl(-ethylamine, previously isolated from the tunicate Didemnum candidum, but the remaining four indoles [2-5] are novel compounds. These showed anti-serotonin activity and a strong affinity for somatostatin and neuropeptide Y receptors in receptor-binding assays.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Calcitonin Gene-Related Peptide / metabolism
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Cell Line
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Galanin / metabolism
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Guinea Pigs
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Humans
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Indoles / isolation & purification*
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Indoles / pharmacology
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Magnetic Resonance Spectroscopy
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Male
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New Caledonia
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Porifera / chemistry*
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Rats
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Receptors, AMPA / antagonists & inhibitors
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Receptors, N-Methyl-D-Aspartate / drug effects
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Receptors, Neurotensin / drug effects
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Receptors, Vasoactive Intestinal Peptide / drug effects
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Serotonin Antagonists / isolation & purification
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Serotonin Antagonists / pharmacology
Substances
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Alkaloids
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Indoles
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Receptors, AMPA
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotensin
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Receptors, Vasoactive Intestinal Peptide
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Serotonin Antagonists
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gelliusine A
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Galanin
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Calcitonin Gene-Related Peptide