Antibiotic GE37468 A: a new inhibitor of bacterial protein synthesis. I. Isolation and characterization

S Stella; N Montanini; F Le Monnier; P Ferrari; L Colombo; F Marinelli; P Landini; I Ciciliato; B P Goldstein; E Selva

doi:10.7164/antibiotics.48.780

Antibiotic GE37468 A: a new inhibitor of bacterial protein synthesis. I. Isolation and characterization

J Antibiot (Tokyo). 1995 Aug;48(8):780-6. doi: 10.7164/antibiotics.48.780.

Authors

S Stella¹, N Montanini, F Le Monnier, P Ferrari, L Colombo, F Marinelli, P Landini, I Ciciliato, B P Goldstein, E Selva, et al.

Affiliation

¹ Marion Merrell Dow Research Institute, Lepetit Research Center, Gerenzano VA, Italy.

PMID: 7592021
DOI: 10.7164/antibiotics.48.780

Abstract

GE37468 A is a new thiazolyl peptide antibiotic obtained by fermentation of Streptomyces sp. strain ATCC 55365. It inhibits bacterial protein synthesis by acting on elongation factor Tu and is structurally and functionally related to the GE2270 class of EF-Tu inhibitors. It is active in vitro against Gram-positive bacteria and Bacteroides fragilis, and protects mice against Staphylococcus aureus infection.

Publication types

Comparative Study

MeSH terms

Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Bacillus subtilis / drug effects
Bacillus subtilis / metabolism
Bacterial Proteins / biosynthesis
Bacteroides fragilis / drug effects
Chromatography, High Pressure Liquid
Female
Gram-Positive Bacteria / drug effects
Gram-Positive Bacteria / metabolism
Male
Mice
Microbial Sensitivity Tests
Molecular Structure
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification
Peptides, Cyclic / pharmacology
Rats
Staphylococcal Infections / drug therapy
Streptomyces
Thiazoles / chemistry
Thiazoles / isolation & purification*
Thiazoles / pharmacology

Substances

Anti-Bacterial Agents
Bacterial Proteins
GE 37468 A
Peptides, Cyclic
Thiazoles
GE 2270 A