Abstract
GERI-BP001 compounds, new inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT), were isolated from a culture broth of Aspergillus fumigatus F37 by acetone extraction, EtOAc extraction, SiO2 column chromatography, and reverse phase HPLC. GERI-BP001 M, A, and B inhibit ACAT activity in an enzyme assay system using rat liver microsomes by 50% at concentrations of 42, 94, and 40 microM, respectively.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Aspergillus fumigatus
-
Enzyme Inhibitors / chemistry
-
Enzyme Inhibitors / isolation & purification*
-
Enzyme Inhibitors / pharmacology
-
Fermentation
-
Microbial Sensitivity Tests
-
Microsomes, Liver / drug effects
-
Pyridines / chemistry
-
Pyridines / isolation & purification*
-
Pyridines / pharmacology
-
Rats
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / isolation & purification*
-
Sesquiterpenes / pharmacology
-
Sterol O-Acyltransferase / antagonists & inhibitors*
Substances
-
Enzyme Inhibitors
-
GERI-BP001 A
-
GERI-BP001 B
-
GERI-BP001 M
-
Pyridines
-
Sesquiterpenes
-
Sterol O-Acyltransferase