Immunoreactivity of ageing C57BL female mice rendered tolerant to the H-Y antigen

Folia Biol (Praha). 1994;40(6):477-82.

Abstract

Transplantation tolerance to the H-Y antigen, induced in neonatal or young adult C57BL female mice, beneficially affected their immunoreactivity during the process of ageing. The tolerance acquired in 2-month-old females significantly increased their splenocyte graft-versus-host (GVH) reactivity and the production of interleukin-2 (IL-2) at the age of 18 months. The neonatally induced tolerance also resulted in a higher weight of the thymus and a significantly enhanced GVH reactivity of thymocytes in 18-month-old females compared to control mice of the same age.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / immunology*
  • Animals
  • Animals, Newborn
  • Female
  • Graft vs Host Reaction*
  • H-Y Antigen / immunology*
  • Immune Tolerance*
  • Immunosuppression Therapy
  • Interleukin-2 / biosynthesis
  • Lymphocyte Transfusion*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Organ Size
  • Spleen / anatomy & histology
  • Spleen / growth & development
  • Spleen / transplantation
  • Thymus Gland / anatomy & histology
  • Thymus Gland / growth & development
  • Transplantation, Isogeneic

Substances

  • H-Y Antigen
  • Interleukin-2