Data on the incidence and deaths of hemorrhagic fever with kidney syndrome (HFKS) in Serbia 1979-1992 were analyzed. Mostly sporadic cases of illness were registered, but for two years it was epidemy in 1986., with 34 and in 1989., with 42 ill. The morbidity rate was between 0.01 and 0.72 /10000 (on average 0.16 /0000). Most often men (72.7%) between 20-39 years old, industrial workers (33.3%) got affected, whose place of living was in the rural environment. The lethality rate was high--7.6%, in epidemies 11.8%, and during sporadic occurrence 1.8%. The ill were registered during the whole year, but the characteristic season of illness was May--September with 76.3% of the total number of the ill. The topographic distribution of the ill showed that the greatest number of the ill with HFKS (45.8%) occurred in three counties in Serbia--in Ivanjica, Cacak and Lucani.