A preliminary investigation of chlorinated hydrocarbons and chronic fatigue syndrome

Med J Aust. 1995 Sep 18;163(6):294-7. doi: 10.5694/j.1326-5377.1995.tb124593.x.

Abstract

Objective: To determine whether serum levels of chlorinated hydrocarbons are elevated in patients with chronic fatigue syndrome.

Methods: Chlorinated hydrocarbon levels were measured in 22 patients with chronic fatigue syndrome (CFS) (as defined by the Centers for Disease Control [CDC]); in 17 patients with CFS symptoms whose history of exposure to toxic chemicals excluded them from the research definition of CFS; and in 34 non-CFS control subjects matched for age and sex.

Results: DDE (1,1-dichloro-2,2-bis (p-chlorophenyl) ethene) was detected in all serum samples at levels over 0.4 ppb. The incidence of hexachlorobenzene (HCB) contamination (> 2.0 ppb) was 45% in the CFS group, compared with 21% in the non-CFS control group (P < 0.05). The CFS group had a significantly higher total organochlorine level (15.9 ppb; SEM, 4.4) than the control group (6.3 ppb; SEM, 1.1; P < 0.05). The toxic exposure group also had a higher mean organochlorine level (13.6 ppb; SEM, 6.2) than the control group, but the difference was not statistically significant. DDE and HCB comprised more than 90% of the total organochlorines measured in each of the groups.

Conclusion: The results suggest that recalcitrant organochlorines may have an aetiological role in CFS. There were no significant differences in serum organochlorine concentrations between CFS patients and chronic fatigue patients with a history of toxic chemical exposure. Therefore, exclusion of patients from the CDC research definition of CFS on the basis of a reported history of known exposure to toxic chemicals is not valid. The role of low-level organochlorine bioaccumulation in the development of CFS symptoms requires further investigation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Dichlorodiphenyl Dichloroethylene / adverse effects*
  • Dichlorodiphenyl Dichloroethylene / blood
  • Environmental Exposure
  • Fatigue Syndrome, Chronic / blood
  • Fatigue Syndrome, Chronic / chemically induced*
  • Female
  • Humans
  • Male
  • Middle Aged

Substances

  • Dichlorodiphenyl Dichloroethylene