Proposed structure of the A domains of factor VIII by homology modelling

Nat Struct Biol. 1995 Sep;2(9):740-4. doi: 10.1038/nsb0995-740.

Abstract

We have predicted a structure for the three A domains of blood coagulation factor VIII by virtue of their homology to blue copper-binding proteins. This structure, consisting of six beta-barrels, is arranged in a triangular configuration with a single type II copper-binding site linking the A1 and A3 domains.

Publication types

  • Letter

MeSH terms

  • Amino Acid Sequence
  • Ascorbate Oxidase / chemistry
  • Ascorbate Oxidase / metabolism
  • Binding Sites
  • Ceruloplasmin / chemistry
  • Ceruloplasmin / metabolism
  • Copper / metabolism
  • Factor VIII / chemistry*
  • Factor VIII / metabolism
  • Humans
  • Molecular Sequence Data
  • Nitrite Reductases / chemistry
  • Nitrite Reductases / metabolism
  • Protein Conformation
  • Sequence Alignment
  • Sequence Homology, Amino Acid*

Substances

  • Copper
  • Factor VIII
  • Ascorbate Oxidase
  • Ceruloplasmin
  • Nitrite Reductases