Abstract
We have predicted a structure for the three A domains of blood coagulation factor VIII by virtue of their homology to blue copper-binding proteins. This structure, consisting of six beta-barrels, is arranged in a triangular configuration with a single type II copper-binding site linking the A1 and A3 domains.
MeSH terms
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Amino Acid Sequence
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Ascorbate Oxidase / chemistry
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Ascorbate Oxidase / metabolism
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Binding Sites
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Ceruloplasmin / chemistry
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Ceruloplasmin / metabolism
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Copper / metabolism
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Factor VIII / chemistry*
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Factor VIII / metabolism
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Humans
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Molecular Sequence Data
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Nitrite Reductases / chemistry
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Nitrite Reductases / metabolism
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Protein Conformation
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Sequence Alignment
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Sequence Homology, Amino Acid*
Substances
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Copper
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Factor VIII
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Ascorbate Oxidase
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Ceruloplasmin
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Nitrite Reductases