Abstract
Computer modelling of the antithrombin III-heparin-thrombin complex inspired the synthesis of novel glycoconjugates, whose factor Xa and thrombin inhibitory activities can be adjusted in a rational way, leading to anticoagulants with unprecedented characteristics.
MeSH terms
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Anticoagulants / chemistry*
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Anticoagulants / metabolism
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Anticoagulants / pharmacology
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Antithrombin III / chemistry
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Carbohydrate Sequence
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Drug Design
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Factor Xa Inhibitors
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Heparin / analogs & derivatives*
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Heparin / chemistry*
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Molecular Sequence Data
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Polysaccharides / chemistry
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Polysaccharides / metabolism
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Protein Conformation
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Structure-Activity Relationship
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Thrombin / antagonists & inhibitors
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Thrombin / metabolism
Substances
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Anticoagulants
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Factor Xa Inhibitors
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Polysaccharides
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Antithrombin III
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Heparin
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Thrombin