Rational design of synthetic heparin analogues with tailor-made coagulation factor inhibitory activity

Nat Struct Biol. 1995 Sep;2(9):736-9. doi: 10.1038/nsb0995-736.

Abstract

Computer modelling of the antithrombin III-heparin-thrombin complex inspired the synthesis of novel glycoconjugates, whose factor Xa and thrombin inhibitory activities can be adjusted in a rational way, leading to anticoagulants with unprecedented characteristics.

Publication types

  • Letter

MeSH terms

  • Anticoagulants / chemistry*
  • Anticoagulants / metabolism
  • Anticoagulants / pharmacology
  • Antithrombin III / chemistry
  • Carbohydrate Sequence
  • Drug Design
  • Factor Xa Inhibitors
  • Heparin / analogs & derivatives*
  • Heparin / chemistry*
  • Molecular Sequence Data
  • Polysaccharides / chemistry
  • Polysaccharides / metabolism
  • Protein Conformation
  • Structure-Activity Relationship
  • Thrombin / antagonists & inhibitors
  • Thrombin / metabolism

Substances

  • Anticoagulants
  • Factor Xa Inhibitors
  • Polysaccharides
  • Antithrombin III
  • Heparin
  • Thrombin