Comparison of apo A-I-containing subpopulations of dog plasma and prenodal peripheral lymph: evidence for alteration in subpopulations in the interstitial space

Biochim Biophys Acta. 1993 Sep 8;1169(3):301-4. doi: 10.1016/0005-2760(93)90254-7.

Abstract

To study in vivo reverse cholesterol transport, dog plasma and lymph apo A-I-containing subpopulations were compared by two-dimensional electrophoresis. Charge and size of subpopulations were similar in plasma and lymph, but the distribution of subpopulations varied considerably. An increase in pre-beta and pre-alpha particles in lymph suggests these changes are a reflection of in vivo reverse cholesterol transport.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apolipoprotein A-I / analysis*
  • Biological Transport
  • Cholesterol / metabolism
  • Dogs
  • Electrophoresis, Gel, Two-Dimensional / methods*
  • Extracellular Space / chemistry*
  • Lipoproteins, HDL / blood*
  • Lipoproteins, HDL / chemistry
  • Lipoproteins, HDL / isolation & purification
  • Lymph / chemistry*

Substances

  • Apolipoprotein A-I
  • Lipoproteins, HDL
  • Cholesterol