Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues

E Petrangeli; C Lubrano; L Ravenna; A Vacca; M R Cardillo; L Salvatori; F Sciarra; L Frati; A Gulino

doi:10.1038/bjc.1995.444

Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues

Br J Cancer. 1995 Oct;72(4):973-5. doi: 10.1038/bjc.1995.444.

Authors

E Petrangeli¹, C Lubrano, L Ravenna, A Vacca, M R Cardillo, L Salvatori, F Sciarra, L Frati, A Gulino

Affiliation

¹ Institute of Biomedical Technology, CNR, Rome, Italy.

Abstract

Oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) gene methylation was evaluated in neoplastic and perineoplastic breast tissues from 20 patients. In both tissues, ER gene methylation was inversely correlated with protein levels, while EGFR gene methylation was not. A preferential ER gene hypomethylation was found in neoplastic tissues, suggesting a significant role in neoplastic transformation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms / metabolism*
DNA / metabolism*
ErbB Receptors / genetics*
Female
Humans
Methylation
Receptors, Estrogen / genetics*

Substances

Receptors, Estrogen
DNA
ErbB Receptors