Abstract
Juvenile hormone analogues were tested for their lytic activity on Trypanosoma cruzi Chagas, 1909 blood tripomastigotes cultivated in vitro. The results indicated that the carbamate 4 and the phenoxyphenol derivative 1 are considered good candidates for blood sterilization. The compounds were also assayed for inhibition of development of parasites in infected mice showing a moderated degree of activity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carbamates / pharmacology
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Chagas Disease / drug therapy*
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Juvenile Hormones / pharmacology*
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Juvenile Hormones / therapeutic use*
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Mice
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Phenols / pharmacology
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Structure-Activity Relationship
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Trypanocidal Agents / pharmacology*
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Trypanocidal Agents / therapeutic use*
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Trypanosoma cruzi / drug effects
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Trypanosoma cruzi / growth & development*
Substances
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Carbamates
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Juvenile Hormones
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Phenols
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Trypanocidal Agents