Effects of juvenile hormone analogues (JHA) on the development of Trypanosoma cruzi

Z Naturforsch C J Biosci. 1995 Jul-Aug;50(7-8):578-80. doi: 10.1515/znc-1995-7-817.

Abstract

Juvenile hormone analogues were tested for their lytic activity on Trypanosoma cruzi Chagas, 1909 blood tripomastigotes cultivated in vitro. The results indicated that the carbamate 4 and the phenoxyphenol derivative 1 are considered good candidates for blood sterilization. The compounds were also assayed for inhibition of development of parasites in infected mice showing a moderated degree of activity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbamates / pharmacology
  • Chagas Disease / drug therapy*
  • Juvenile Hormones / pharmacology*
  • Juvenile Hormones / therapeutic use*
  • Mice
  • Phenols / pharmacology
  • Structure-Activity Relationship
  • Trypanocidal Agents / pharmacology*
  • Trypanocidal Agents / therapeutic use*
  • Trypanosoma cruzi / drug effects
  • Trypanosoma cruzi / growth & development*

Substances

  • Carbamates
  • Juvenile Hormones
  • Phenols
  • Trypanocidal Agents