Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats

Brain Res. 1995 May 8;679(1):184-7. doi: 10.1016/0006-8993(95)00217-e.

Abstract

We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Oxidoreductases / antagonists & inhibitors*
  • Animals
  • Arginine / analogs & derivatives*
  • Arginine / pharmacology
  • Drug Synergism
  • Injections, Intraperitoneal
  • Kainic Acid / pharmacology*
  • Male
  • Nitric Oxide Synthase
  • Nitroarginine
  • Pilocarpine / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Seizures / chemically induced*

Substances

  • Pilocarpine
  • Nitroarginine
  • Arginine
  • Nitric Oxide Synthase
  • Amino Acid Oxidoreductases
  • Kainic Acid