Influence of hepatitis C virus (HCV) genotypes on HCV recombinant immunoblot assay patterns

J M Pawlotsky; F Roudot-Thoraval; C Pellet; P Aumont; F Darthuy; J Remire; J Duval; D Dhumeaux

doi:10.1128/jcm.33.5.1357-1359.1995

Influence of hepatitis C virus (HCV) genotypes on HCV recombinant immunoblot assay patterns

J Clin Microbiol. 1995 May;33(5):1357-9. doi: 10.1128/jcm.33.5.1357-1359.1995.

Authors

J M Pawlotsky¹, F Roudot-Thoraval, C Pellet, P Aumont, F Darthuy, J Remire, J Duval, D Dhumeaux

Affiliation

¹ Department of Bacteriology and Virology, Hôpital Henri Mondor, Université Paris XII, Créteil, France.

Abstract

Ninety-six patients with chronic hepatitis C were studied. A second-generation recombinant immunoblot assay detected anti-NS4 antibodies significantly more often in patients infected by hepatitis C virus genotype 1 than in patients infected by other types. By a third-generation recombinant immunoblot assay, the prevalences of the four antibodies measured did not differ according to the hepatitis C virus genotype.

Publication types

Comparative Study

MeSH terms

Antigens, Viral
Enzyme-Linked Immunosorbent Assay
Genotype
Hepacivirus / classification
Hepacivirus / genetics*
Hepacivirus / immunology*
Hepatitis Antibodies / blood*
Hepatitis C / immunology
Hepatitis C / virology
Hepatitis C Antibodies
Hepatitis C Antigens
Hepatitis, Chronic / immunology
Hepatitis, Chronic / virology
Humans
Immunoblotting / methods*
Viral Nonstructural Proteins / immunology
Virology / methods*

Substances

Antigens, Viral
Hepatitis Antibodies
Hepatitis C Antibodies
Hepatitis C Antigens
NS4 protein, hepatitis C virus
Viral Nonstructural Proteins