Abstract
A 74-year-old woman with a sensory neuropathy and IgM M-protein monoclonal gammopathy of undetermined significance developed a fatal B-cell cerebral lymphoma. CSF protein immunofixation revealed intrathecal secretion of a paraprotein of the same heavy- and light-chain isotypes as the serum monoclonal component (IgM-lambda). Reactivation of Epstein-Barr virus was present in the lymphoma cells. Different factors may be involved in the preferential malignant development of the monoclonal B-cell clone within the CNS.
MeSH terms
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Aged
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Brain / diagnostic imaging
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Brain / pathology
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Brain / virology
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Brain Neoplasms / complications*
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Brain Neoplasms / diagnostic imaging
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Brain Neoplasms / pathology
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Brain Neoplasms / virology
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Enzyme-Linked Immunosorbent Assay
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Fatal Outcome
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Female
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Gadolinium
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Gadolinium DTPA
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Herpesvirus 4, Human / isolation & purification
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Humans
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Immunoglobulin M / blood*
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Lymphoma, B-Cell / complications*
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Lymphoma, B-Cell / diagnostic imaging
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Lymphoma, B-Cell / pathology
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Lymphoma, B-Cell / virology
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Myelin Proteins / immunology*
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Myelin-Associated Glycoprotein
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Organometallic Compounds
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Paraproteinemias / complications*
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Paraproteinemias / diagnostic imaging
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Pentetic Acid / analogs & derivatives
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Peripheral Nervous System Diseases / complications*
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Radionuclide Imaging
Substances
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Immunoglobulin M
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Myelin Proteins
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Myelin-Associated Glycoprotein
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Organometallic Compounds
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Pentetic Acid
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Gadolinium
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Gadolinium DTPA