High-grade B-cell cerebral lymphoma in a patient with anti-myelin-associated glycoprotein IgM paraproteinemic neuropathy

Neurology. 1995 Feb;45(2):378-81. doi: 10.1212/wnl.45.2.378.

Abstract

A 74-year-old woman with a sensory neuropathy and IgM M-protein monoclonal gammopathy of undetermined significance developed a fatal B-cell cerebral lymphoma. CSF protein immunofixation revealed intrathecal secretion of a paraprotein of the same heavy- and light-chain isotypes as the serum monoclonal component (IgM-lambda). Reactivation of Epstein-Barr virus was present in the lymphoma cells. Different factors may be involved in the preferential malignant development of the monoclonal B-cell clone within the CNS.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Brain / diagnostic imaging
  • Brain / pathology
  • Brain / virology
  • Brain Neoplasms / complications*
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / pathology
  • Brain Neoplasms / virology
  • Enzyme-Linked Immunosorbent Assay
  • Fatal Outcome
  • Female
  • Gadolinium
  • Gadolinium DTPA
  • Herpesvirus 4, Human / isolation & purification
  • Humans
  • Immunoglobulin M / blood*
  • Lymphoma, B-Cell / complications*
  • Lymphoma, B-Cell / diagnostic imaging
  • Lymphoma, B-Cell / pathology
  • Lymphoma, B-Cell / virology
  • Myelin Proteins / immunology*
  • Myelin-Associated Glycoprotein
  • Organometallic Compounds
  • Paraproteinemias / complications*
  • Paraproteinemias / diagnostic imaging
  • Pentetic Acid / analogs & derivatives
  • Peripheral Nervous System Diseases / complications*
  • Radionuclide Imaging

Substances

  • Immunoglobulin M
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA