Genotoxicity testing of five compounds in three Drosophila short-term somatic assays

Mutat Res. 1995 Jan;341(3):161-7. doi: 10.1016/0165-1218(95)90006-3.

Abstract

To provide further background data for the somatic mutation and/or recombination tests in Drosophila melanogaster, we have evaluated the response in 3 assays (zeste-white, white-ivory and wing spot) of 5 chemicals classified by the U.S. National Toxicology Program (NTP) as genotoxic non-carcinogens (or ambiguous). The selected compounds were 2-chloromethylpyridine, 1-nitronaphthalene, 4-nitro-o-phenylenediamine, 3-nitropropionic acid and p-phenylenediamine. Our results show that all the compounds tested produce significant increases in the frequency of mutant clones, in at least one of the assays, p-phenylenediamine being the compound which presents a clearer mutagenic activity, and the wing spot test, the assay that detects more genotoxic compounds (4/5).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drosophila melanogaster / drug effects*
  • Drosophila melanogaster / genetics
  • Female
  • Male
  • Mutagenicity Tests / standards*
  • Mutagens / toxicity*
  • Naphthalenes / toxicity
  • Nitro Compounds
  • Phenylenediamines / toxicity
  • Picolines / toxicity*
  • Propionates / toxicity

Substances

  • Mutagens
  • Naphthalenes
  • Nitro Compounds
  • Phenylenediamines
  • Picolines
  • Propionates
  • 2-chloromethylpyridine
  • 1,2-diamino-4-nitrobenzene
  • 1-nitronaphthalene
  • 3-nitropropionic acid
  • 4-phenylenediamine