Abstract
A new diterpenoid, megathyrin A, together with three known compounds, rabdocoetsins B, C, and D, were isolated from the leaves of Isodon megathyrsus, and their structures and nmr spectral data were assigned by a combination of one- and two-dimensional nmr techniques. These compounds displayed significant cytotoxic activity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antimalarials / isolation & purification
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Antimalarials / pharmacology
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Survival / drug effects
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / pharmacology*
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HIV Reverse Transcriptase
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Magnetic Resonance Spectroscopy
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Medicine, Chinese Traditional
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Reverse Transcriptase Inhibitors
Substances
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Antimalarials
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Drugs, Chinese Herbal
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Reverse Transcriptase Inhibitors
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HIV Reverse Transcriptase