Abstract
Serum sE-selectin levels in KD were tested. In the KD patients' sera during the acute phase, the levels of circulating sE-selectin were markedly elevated (27.5 +/- 10.9 ng/ml) compared to 3.1 +/- 1.0 ng/ml in the control subjects (p < 0.0001). The serum sE-selectin levels remained significantly elevated in the subacute phase (16.2 +/- 7.3 ng/ml; p < 0.005). The acute phase sE-selectin levels and TNF-alpha correlated well in a linear pattern (r2 = 0.64, p < 0.01). Also the acute phase sE-selectin levels and IL-6 were well correlated (r2 = 0.54, p < 0.05). The elevated serum sE-selectin levels in patients with KD provides additional evidence for the relationship between acute vasculitis and serum sE-selectin.
MeSH terms
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Acute-Phase Proteins / analysis*
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Acute-Phase Proteins / biosynthesis
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Acute-Phase Reaction / immunology
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Biomarkers / blood
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Cell Adhesion Molecules / biosynthesis
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Cell Adhesion Molecules / blood*
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Child
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Child, Preschool
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Coronary Disease / etiology
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Coronary Disease / prevention & control
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E-Selectin
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Female
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Humans
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Infant
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Interleukin-6 / biosynthesis
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Interleukin-6 / blood
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Male
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Mucocutaneous Lymph Node Syndrome / immunology*
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Mucocutaneous Lymph Node Syndrome / physiopathology*
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Receptors, Immunologic / analysis*
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Receptors, Immunologic / biosynthesis
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Regression Analysis
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Severity of Illness Index
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Tumor Necrosis Factor-alpha / analysis
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Acute-Phase Proteins
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Biomarkers
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Cell Adhesion Molecules
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E-Selectin
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Interleukin-6
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Receptors, Immunologic
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Tumor Necrosis Factor-alpha