Identification of glioma-associated antigen MUC 2-63 as CD44

Br J Cancer. 1994 Nov;70(5):799-803. doi: 10.1038/bjc.1994.402.

Abstract

Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies using MUC 2-63 and the CD44 anti-framework antibody F10-44-2. Thus not only MUC 2-63 but also other anti-CD44 monoclonal antibodies should prove useful in imaging and, perhaps, therapy of brain tumours.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / immunology
  • Antibody Specificity
  • Antigens, Neoplasm / analysis*
  • Antigens, Neoplasm / immunology
  • Blotting, Western
  • Carrier Proteins / analysis*
  • Carrier Proteins / immunology
  • Colon / chemistry
  • Flow Cytometry
  • Glioma / chemistry*
  • Humans
  • Hyaluronan Receptors
  • Immunohistochemistry
  • Molecular Weight
  • Receptors, Cell Surface / analysis*
  • Receptors, Cell Surface / immunology
  • Receptors, Lymphocyte Homing / analysis*
  • Receptors, Lymphocyte Homing / immunology
  • Skin / chemistry
  • Thymus Gland / chemistry

Substances

  • Antibodies
  • Antigens, Neoplasm
  • Carrier Proteins
  • Hyaluronan Receptors
  • Receptors, Cell Surface
  • Receptors, Lymphocyte Homing