Salmeterol inhibits anaphylactic histamine release from guinea-pig isolated mast cells

J Pharm Pharmacol. 1994 Jan;46(1):76-7. doi: 10.1111/j.2042-7158.1994.tb03725.x.

Abstract

Salmeterol (1 nM-100 microM) showed an inhibitory action on anaphylactic histamine release from mast cells, isolated from pleural and peritoneal cavities of actively sensitized guinea-pigs and stimulated by incubation with allergen. The effect is concentration-dependent and is reduced by the beta-adrenoceptor antagonist propranolol (1 microM). This study supports the hypothesis of an anti-inflammatory property of salmeterol, which concerns cells involved in the early phases of asthma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Agonists / pharmacology*
  • Albuterol / analogs & derivatives*
  • Albuterol / pharmacology
  • Anaphylaxis / drug therapy*
  • Animals
  • Fluorometry
  • Guinea Pigs
  • Histamine Antagonists / pharmacology*
  • Histamine Release / drug effects*
  • In Vitro Techniques
  • Male
  • Mast Cells / drug effects*
  • Peritoneal Cavity / cytology
  • Pleura / cytology
  • Propranolol / pharmacology
  • Salmeterol Xinafoate

Substances

  • Adrenergic beta-Agonists
  • Histamine Antagonists
  • Salmeterol Xinafoate
  • Propranolol
  • Albuterol