Abstract
Salmeterol (1 nM-100 microM) showed an inhibitory action on anaphylactic histamine release from mast cells, isolated from pleural and peritoneal cavities of actively sensitized guinea-pigs and stimulated by incubation with allergen. The effect is concentration-dependent and is reduced by the beta-adrenoceptor antagonist propranolol (1 microM). This study supports the hypothesis of an anti-inflammatory property of salmeterol, which concerns cells involved in the early phases of asthma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic beta-Agonists / pharmacology*
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Albuterol / analogs & derivatives*
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Albuterol / pharmacology
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Anaphylaxis / drug therapy*
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Animals
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Fluorometry
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Guinea Pigs
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Histamine Antagonists / pharmacology*
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Histamine Release / drug effects*
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In Vitro Techniques
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Male
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Mast Cells / drug effects*
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Peritoneal Cavity / cytology
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Pleura / cytology
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Propranolol / pharmacology
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Salmeterol Xinafoate
Substances
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Adrenergic beta-Agonists
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Histamine Antagonists
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Salmeterol Xinafoate
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Propranolol
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Albuterol