Abstract
Interactions between cells from human giant cell tumors of bone and the extracellular matrix protein laminin were studied. Cells were capable of recognizing this substratum via a RGD-independent mechanism. Recognition induces adhesion and spreading onto laminin. This protein triggered the release of cellular FN which in turn enhanced recruitment of the beta 1 chain-containing integrin receptor.
MeSH terms
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Amino Acid Sequence
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Bone Neoplasms / pathology
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Cell Adhesion / drug effects
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Fibronectins / metabolism
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Giant Cell Tumor of Bone / pathology
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Humans
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Integrin beta1
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Integrins / metabolism
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Laminin / metabolism*
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Molecular Sequence Data
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Oligopeptides* / pharmacology*
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Osteoclasts / drug effects
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Osteoclasts / metabolism*
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Receptors, Laminin / metabolism
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Tumor Cells, Cultured
Substances
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Fibronectins
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Integrin beta1
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Integrins
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Laminin
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Oligopeptides
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Receptors, Laminin
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arginyl-glycyl-aspartic acid
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glycyl-arginyl-glycyl-aspartyl-seryl-proline
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glycyl-arginyl-glycyl-glutamyl-seryl-proline