Abstract
Immunization of mice with a recombinant vaccinia virus expressing the human papillomavirus type 16 (HPV-16) E6 gene elicits specific antibody, proliferative and cytotoxic T lymphocyte responses. T and B cell epitopes were mapped by using synthetic peptides. This study provides the background to future investigation aimed at developing prophylactic and therapeutic vaccines against HPV-16 infection and cervical cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Viral / biosynthesis
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B-Lymphocytes / immunology
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Base Sequence
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DNA-Binding Proteins*
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Epitopes
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Female
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Genetic Vectors
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Mice
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Mice, Inbred C57BL
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Mice, Inbred DBA
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Molecular Sequence Data
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Oncogene Proteins, Viral / biosynthesis
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Oncogene Proteins, Viral / genetics
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Oncogene Proteins, Viral / immunology*
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Papillomaviridae / genetics
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Papillomaviridae / immunology*
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T-Lymphocytes / immunology
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T-Lymphocytes, Cytotoxic / immunology
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Vaccines, Synthetic / biosynthesis
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Vaccines, Synthetic / immunology*
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Vaccinia virus / genetics*
Substances
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Antibodies, Viral
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DNA-Binding Proteins
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E6 protein, Human papillomavirus type 18
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Epitopes
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Oncogene Proteins, Viral
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Vaccines, Synthetic