Immune response to human papillomavirus type 16 E6 gene in a live vaccinia vector

J Gen Virol. 1994 Jan:75 ( Pt 1):157-64. doi: 10.1099/0022-1317-75-1-157.

Abstract

Immunization of mice with a recombinant vaccinia virus expressing the human papillomavirus type 16 (HPV-16) E6 gene elicits specific antibody, proliferative and cytotoxic T lymphocyte responses. T and B cell epitopes were mapped by using synthetic peptides. This study provides the background to future investigation aimed at developing prophylactic and therapeutic vaccines against HPV-16 infection and cervical cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Viral / biosynthesis
  • B-Lymphocytes / immunology
  • Base Sequence
  • DNA-Binding Proteins*
  • Epitopes
  • Female
  • Genetic Vectors
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Molecular Sequence Data
  • Oncogene Proteins, Viral / biosynthesis
  • Oncogene Proteins, Viral / genetics
  • Oncogene Proteins, Viral / immunology*
  • Papillomaviridae / genetics
  • Papillomaviridae / immunology*
  • T-Lymphocytes / immunology
  • T-Lymphocytes, Cytotoxic / immunology
  • Vaccines, Synthetic / biosynthesis
  • Vaccines, Synthetic / immunology*
  • Vaccinia virus / genetics*

Substances

  • Antibodies, Viral
  • DNA-Binding Proteins
  • E6 protein, Human papillomavirus type 18
  • Epitopes
  • Oncogene Proteins, Viral
  • Vaccines, Synthetic