Abstract
Receptor-type tyrosine kinases (RTKs) constitute a family of proteins involved in growth and developmental processes. Class III RTKs are characterized by an extracellular region composed of five immunoglobulin-like domains and by a split tyrosine kinase domain. Some of the class III RTKs perform major functions in hematopoiesis and are the focus of this review. They are the colony-stimulating factor-1 (CSF1) and Steel factor (SLF) receptors, encoded by the FMS and KIT protooncogenes, respectively, and the product of the FLT3/FLK2 gene. The structural, biochemical, functional, and pathological features of these three receptors and genes are reviewed.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Female
-
Hematopoiesis / physiology*
-
Hematopoietic Cell Growth Factors / genetics
-
Hematopoietic Cell Growth Factors / physiology
-
Humans
-
Mice
-
Protein-Tyrosine Kinases / genetics
-
Protein-Tyrosine Kinases / physiology
-
Proto-Oncogene Proteins / genetics
-
Proto-Oncogene Proteins / physiology
-
Proto-Oncogene Proteins c-kit
-
Proto-Oncogenes
-
Receptor Protein-Tyrosine Kinases / genetics
-
Receptor Protein-Tyrosine Kinases / physiology*
-
Receptors, Cell Surface / genetics
-
Receptors, Cell Surface / physiology
-
Receptors, Colony-Stimulating Factor / genetics
-
Receptors, Colony-Stimulating Factor / physiology
-
Signal Transduction / physiology
-
Stem Cell Factor
-
Stem Cells / physiology
-
fms-Like Tyrosine Kinase 3
Substances
-
Hematopoietic Cell Growth Factors
-
Proto-Oncogene Proteins
-
Receptors, Cell Surface
-
Receptors, Colony-Stimulating Factor
-
Stem Cell Factor
-
FLT3 protein, human
-
Flt3 protein, mouse
-
Protein-Tyrosine Kinases
-
Proto-Oncogene Proteins c-kit
-
Receptor Protein-Tyrosine Kinases
-
fms-Like Tyrosine Kinase 3