Ifosfamide-induced renal tubular defect

Med Pediatr Oncol. 1994;22(2):144-6. doi: 10.1002/mpo.2950220217.

Abstract

We describe 2 cases of proximal tubular defects induced by the administration of ifosfamide at a dosage of 6 g/m2/course over 2 days in children with a diagnosis of malignant mesenchymal tumors. This adverse effect could be minimized dividing dosage of the drug. However at present it is not clear if divided doses are completely safe.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cyclophosphamide / administration & dosage
  • Dactinomycin / administration & dosage
  • Doxorubicin / administration & dosage
  • Humans
  • Ifosfamide / administration & dosage
  • Ifosfamide / adverse effects*
  • Infant
  • Infant, Newborn
  • Kidney Diseases / chemically induced*
  • Male
  • Rhabdomyosarcoma / drug therapy*
  • Urinary Bladder Neoplasms / drug therapy*
  • Vincristine / administration & dosage

Substances

  • Dactinomycin
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Ifosfamide

Supplementary concepts

  • IVA protocol
  • VACA protocol