Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2

Genomics. 1993 Sep;17(3):759-61. doi: 10.1006/geno.1993.1401.

Abstract

The human CD36 is a member of a gene family of structurally related glycoproteins and functions as a receptor for collagen type I and thrombospondin. CD36 also binds to red blood cells infected with the human malaria parasite Plasmodium falciparum. In the present study, the CD36 gene was assigned to chromosome 7 by using the polymerase chain reaction with DNA from human-hamster somatic cell hybrids. Furthermore, the use of a CD36 genomic probe has allowed the localization of the CD36 locus to the 7q11.2 band by fluorescence in situ hybridization coupled with GTG-banding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • CD36 Antigens
  • Chromosome Mapping
  • Chromosomes, Human, Pair 7*
  • Collagen / metabolism
  • Cricetinae
  • DNA / genetics
  • Humans
  • Hybrid Cells
  • In Situ Hybridization, Fluorescence
  • Integrins / genetics*
  • Membrane Glycoproteins / metabolism
  • Molecular Sequence Data
  • Platelet Membrane Glycoproteins / genetics*
  • Polymerase Chain Reaction
  • Receptors, Collagen
  • Receptors, Cytoadhesin / genetics*
  • Receptors, Immunologic*
  • Receptors, Lipoprotein*
  • Receptors, Scavenger
  • Thrombospondins

Substances

  • CD36 Antigens
  • Integrins
  • Membrane Glycoproteins
  • Platelet Membrane Glycoproteins
  • Receptors, Collagen
  • Receptors, Cytoadhesin
  • Receptors, Immunologic
  • Receptors, Lipoprotein
  • Receptors, Scavenger
  • Thrombospondins
  • Collagen
  • DNA