Abstract
In conclusion, the "M(r) 40kD" antigen is expressed on the apical face of colonic enterocytes often in spatial relation to immune complexes in active UC, apparently targeting an IgG1-mediated autoimmune attack. Thus, our findings support the notion that an autoimmune response to the "M(r) 40kD" antigen, with local production of specific IgG1, is a possible immunopathological mechanism(s) in UC.
MeSH terms
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Autoantigens / chemistry
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Autoantigens / isolation & purification
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Autoantigens / metabolism*
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Colitis, Ulcerative / immunology*
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Colitis, Ulcerative / pathology
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Colon / immunology
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Colon / pathology
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Complement Activation
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Complement System Proteins / isolation & purification
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Complement System Proteins / metabolism*
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Humans
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Immunity, Mucosal
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Immunoglobulin G / isolation & purification
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Immunoglobulin G / metabolism*
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Intestinal Mucosa / immunology*
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Intestinal Mucosa / pathology
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Molecular Weight
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Tissue Distribution
Substances
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Autoantigens
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Immunoglobulin G
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Complement System Proteins