4,5-Dihydro-3-(2-pyrazinyl)naphtho[1,2-c]pyrazole: a potent and selective inhibitor of steroid-17 alpha-hydroxylase-C17,20-lyase (P450 17)

Arch Pharm (Weinheim). 1995 Jul-Aug;328(7-8):573-5. doi: 10.1002/ardp.19953280703.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Enzyme Inhibitors / therapeutic use
  • Humans
  • Male
  • Prostatic Hyperplasia / drug therapy
  • Prostatic Neoplasms / drug therapy
  • Pyrazines / pharmacology*
  • Pyrazoles / chemistry*
  • Pyrazoles / pharmacology*
  • Pyrazoles / therapeutic use
  • Steroid 17-alpha-Hydroxylase / antagonists & inhibitors*
  • Steroid 17-alpha-Hydroxylase / drug effects
  • Structure-Activity Relationship

Substances

  • 4,5-dihydro-3-(2-pyrazinyl)naphtho(1,2-c)pyrazole
  • Enzyme Inhibitors
  • Pyrazines
  • Pyrazoles
  • pyrazole
  • Steroid 17-alpha-Hydroxylase