Abstract
Fluoride-mediated inhibition of peroxidase potential activity in human saliva was investigated using NaF, NH4F, CaF2, Na2PO3F (MFP), SnF2 and TiF4. At pH 5.5 and for a 20 mM F concentration, the inhibition percentages increased from 2% for MFP and 5% for CaF2 to 61% for NaF and 65% for NH4F, while a 100% inhibition was observed at 10 mM for TiF4 and at 5 mM for SnF2. The inhibition was enhanced at acid pH and removed at pH 7. The inhibition could be attributed to ionized F-, except for SnF2 and TiF4, in which part of the inhibition could be imputed to the cations.
MeSH terms
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Calcium Fluoride / pharmacology
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Enzyme Inhibitors / pharmacology*
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Fluorides / pharmacology*
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Fluorides, Topical / pharmacology
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Humans
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Hydrogen-Ion Concentration
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Peroxidase / antagonists & inhibitors*
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Phosphates / pharmacology
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Saliva / enzymology*
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Salivary Proteins and Peptides / antagonists & inhibitors*
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Sodium Fluoride / pharmacology
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Tin Fluorides / pharmacology
Substances
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Enzyme Inhibitors
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Fluorides, Topical
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Phosphates
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Salivary Proteins and Peptides
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Tin Fluorides
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amine fluoride solution
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fluorophosphate
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Sodium Fluoride
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Peroxidase
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Calcium Fluoride
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Fluorides