Abstract
This study was carried out to determine the clinical efficacy and the clinical safety of azithromycin in a group of children with acute respiratory tract infections. The study involved 82 children treated with a single daily 10 mg/kg dose of azithromycin for three consecutive days. 7 days later, the overall clinical response was 100% (cure and improvement): bacteriological cure was achieved in 97.5% of the patients treated. Recurrences were never observed. Side effects not requiring interruption of therapy were observed in 3 patients (3.6%). The side effects were gastrointestinal disturbances. In conclusion azithromycin showed a remarkably clinical efficacy for treatment of acute respiratory infections in children. Tolerability and therapeutic compliance were excellent.
MeSH terms
-
Anti-Bacterial Agents / administration & dosage
-
Anti-Bacterial Agents / pharmacology*
-
Anti-Bacterial Agents / therapeutic use*
-
Azithromycin / administration & dosage
-
Azithromycin / pharmacology*
-
Azithromycin / therapeutic use*
-
Bordetella pertussis / drug effects
-
Bordetella pertussis / isolation & purification
-
Child
-
Child, Preschool
-
Drug Tolerance
-
Female
-
Haemophilus / drug effects
-
Haemophilus / isolation & purification
-
Humans
-
Infant
-
Male
-
Moraxella catarrhalis / drug effects
-
Moraxella catarrhalis / isolation & purification
-
Mycoplasma pneumoniae / drug effects
-
Mycoplasma pneumoniae / isolation & purification
-
Respiratory Tract Infections / diagnosis*
-
Respiratory Tract Infections / microbiology
-
Retrospective Studies
-
Streptococcus / drug effects
-
Streptococcus / isolation & purification
-
Treatment Outcome
Substances
-
Anti-Bacterial Agents
-
Azithromycin