SAA amyloid protein levels in amyloid-prone chronic inflammatory disorders. Lack of association with amyloid disease

J Rheumatol. 1980 Sep-Oct;7(5):724-6.

Abstract

Serum amyloid protein A (SAA) levels were evaluated by a sensitive radioimmunoassay technique in leprosy, juvenile rheumatoid arthritis and chronic osteomyelitis. SAA was elevated in all 3 groups of patients. The level in each of the patient groups did not reflect the presence of secondary amyloidosis. Our study suggests that serum SAA protein levels should not be considered a routine diagnostic test in patients with chronic inflammatory diseases prone to the development of amyloid disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid / blood*
  • Amyloidosis / diagnosis
  • Animals
  • Arthritis, Juvenile / diagnosis*
  • Blood Sedimentation
  • Chronic Disease
  • Female
  • Humans
  • Leprosy / diagnosis*
  • Leukocyte Count
  • Male
  • Osteomyelitis / diagnosis*
  • Rabbits
  • Serum Amyloid A Protein / blood*

Substances

  • Amyloid
  • Serum Amyloid A Protein