Effects of N-trifluoroacetyl adriamycin-14-valerate (AD32) on nuclear RNA synthesis in cultured L1210 cells

Chem Biol Interact. 1980 Nov;32(3):331-7. doi: 10.1016/0009-2797(80)90100-3.

Abstract

N-Trifluoroacetyl adriamycin-14-valerate (AD32), an analog of adriamycin, inhibits nuclear RNA synthesis. It inhibits rRNA, non-poly(A) hnRNA and poly(A) hnRNA with essentially no effect on smaller nuclear RNA species (< 5S).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cells, Cultured
  • DNA Replication / drug effects
  • Dactinomycin / pharmacology
  • Doxorubicin / analogs & derivatives*
  • Doxorubicin / pharmacology
  • Leukemia L1210 / metabolism*
  • Mice
  • RNA, Heterogeneous Nuclear / biosynthesis*

Substances

  • RNA, Heterogeneous Nuclear
  • Dactinomycin
  • valrubicin
  • Doxorubicin