Abstract
N-Trifluoroacetyl adriamycin-14-valerate (AD32), an analog of adriamycin, inhibits nuclear RNA synthesis. It inhibits rRNA, non-poly(A) hnRNA and poly(A) hnRNA with essentially no effect on smaller nuclear RNA species (< 5S).
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cells, Cultured
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DNA Replication / drug effects
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Dactinomycin / pharmacology
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Doxorubicin / analogs & derivatives*
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Doxorubicin / pharmacology
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Leukemia L1210 / metabolism*
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Mice
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RNA, Heterogeneous Nuclear / biosynthesis*
Substances
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RNA, Heterogeneous Nuclear
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Dactinomycin
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valrubicin
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Doxorubicin