Abstract
Nitrosourea derivatives 9--13 which utilize phensuximide (1) as the carrier were synthesized as potential central nervous system antitumor agents. The N-(2-chloroethyl)-N-nitrosourea 13 was active in the mouse ependymoblastoma brain-tumor system, as well as the intraperitoneal L1210 leukemia system.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Brain Neoplasms / drug therapy
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Ependymoma / drug therapy
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Leukemia L1210 / drug therapy
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Mice
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Neoplasms, Experimental / drug therapy
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Nitrosourea Compounds / chemical synthesis*
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Nitrosourea Compounds / pharmacology
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Succinimides / analogs & derivatives*
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Succinimides / chemical synthesis
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Succinimides / pharmacology
Substances
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Antineoplastic Agents
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Nitrosourea Compounds
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Succinimides
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phensuximide