Chemotherapy based upon cellular synchronisation via intra-arterial infusion was used in the treatment of 21 carcinomas of the maxillo-facial region. These tumours had never been treated either by surgery, nor by irradiation. This pre-operative treatment was not aimed at altering ghe indication for the type of operation decided upon at the outset. It was found that a combination of Vincristine, Bleomycine, Methotrexate and Dibromdulcide was more satisfactory than other types of chemotherapy. The most important complication of the method was a thrombosis of the common carotid.