It was established that experimental myocardial infarction leads to a decrease in the ascorbic acid content in the left heart ventricle in the ischemic are and to a negligible rise in the dehydroascorbic acid concentration within the first hours after artery ligation followed by its lowering at the 24th hour. Meanwhile 24 hours after the operation the right heart ventricle manifests a 22% increase in the ascorbic acid content along with the rise of the deketogulonic acid level, whereas the content of dehydroascorbic acid does not appreciably change. The concentration of ascorbic acid in the liver of animals with experimental myocardial infarction drops by 27% as compared with intact animals. The data obtained attest to upset ascorbic acid metabolism in the acute stage of experimental myocardial infarction thus suggesting that it is desirable to apply vitamin C to the treatment of patients with myocardial infarction.