A case of carcinoma of the gallbladder with particular clinic course is described, stressing the problem of the precocious diagnosis of this kind of tumor. The insufficient knowledge about this argument, confirmed by conflicts of the studies about this, is denounced. Considering the far better prognosis when the diagnosis of cancer of the gallbladder is done in the stage "in situ", the AA. confirmed the importance of a careful anamnesis and, above all, of the histological examination on all the gallbladders removed for every cause.