The effect of morpholine in the cure of experimental mycosis caused by Trichophyton mentagrophytes var. granulosum was studied. In all experiments the ointment or gel containing 10% morpholine. The liberation constant of the ointment and gel was k = 1.243 x 10(--1) x k(--1) and k = 3.713 x 10(--1) x k(--1) respectively. After treatment with the ointment or gel on the guinea pig skin, a cure of mycosis was observed. The antimycotic effect of morpholine was demonstrated in histopathological, mycological and clinical study. The effect of morpholine was compared with cream Canesten "Polfa".