An automatic regulator aep (artificial endocrine pancreas) has been developed for the extracorporeal blood glucose regulation. After glucose monitoring, the maschine steers an insulin infusion pump by means of adequate algorithms to obtain a glucose balance in labile diabetic inpatients. This system, also called artificial beta-cell, is a closed loop regulatory system with impulses from the actual blood glucose that represents true feedback principles. So far it is preferably used during surgical operations of labile diabetics and for the intensive therapy of patients with pancreatic affections. The clear therapeutic advantages, that have been found in some special medical centres, give hope that technical ways will be found to master the narrow passes and the difficulties in the future.