Haematological and biochemical characteristics of Heteropneustes fossilis under the stress of Congo Red (diphenyl disazo binaphthionic acid)

M L Sharma; K A Goel; A K Awasthi; S K Tyagi

doi:10.1016/0378-4274(82)90057-1

Haematological and biochemical characteristics of Heteropneustes fossilis under the stress of Congo Red (diphenyl disazo binaphthionic acid)

Toxicol Lett. 1982 Dec;14(3-4):237-41. doi: 10.1016/0378-4274(82)90057-1.

Authors

M L Sharma, K A Goel, A K Awasthi, S K Tyagi

PMID: 7167984
DOI: 10.1016/0378-4274(82)90057-1

Abstract

The effects of the sublethal concentration (0.012%) of Congo Red on Heteropneustes fossilis were studied after 30 days exposure. The RBC count haemoglobin (Hb)% and PCV decreased significantly. The total WBC count, MCV, MCH, and MCHC showed a significant increase. Serum calcium, serum cholesterol and blood urea nitrogen (BUN) were significantly elevated, whereas serum phosphorus was significantly reduced. The activities of serum alkaline phosphatase (AlPase), acid phosphatase (AcPase). RNase, GOT, GPT and amylase were also significantly elevated. The possible reasons for these changes are discussed.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Blood Cell Count
Blood Chemical Analysis
Blood Urea Nitrogen
Congo Red / toxicity*
Fishes / blood*
Hemolysis / drug effects
Hypercholesterolemia / chemically induced

Substances

Congo Red