Normal cortical bone mass in patients after long term coumadin therapy

J Clin Endocrinol Metab. 1982 Feb;54(2):470-3. doi: 10.1210/jcem-54-2-470.

Abstract

Clinical delineation of the warfarin embryopathy and the recent discovery of osteocalcin (a vitamin K-dependent bone protein) suggest that coumadin therapy could adversely affect the skeleton. Using bone densitometry and metacarpal cortical width measurement, we found normal cortical bone mass in 17 adults receiving long term coumadin therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Bone and Bones / anatomy & histology
  • Bone and Bones / drug effects*
  • Densitometry
  • Female
  • Humans
  • Male
  • Metacarpus / anatomy & histology
  • Middle Aged
  • Vitamin K / antagonists & inhibitors
  • Warfarin / pharmacology*
  • Warfarin / therapeutic use

Substances

  • Vitamin K
  • Warfarin